NCT01146444

Sunscreens in Patients With Cutaneous Lupus Erythematosus(CLE)

Investigation of the Efficacy of Different Sunscreens in Patients With Photosensitive Cutaneous Lupus Erythematosus

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Spirig Pharma Ltd. · Industry
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Part I: to investigate the efficacy of different sunscreens in the prevention of skin lesions following standardized photoprovocation with Ultraviolet A/Ultraviolet B (UVA/UVB) light in patients with CLE. Part II: to evaluate the influence of different sunscreens on the expression of biomarkers in the skin of patients with CLE and of Healthy Controls following UV irradiation.

Detailed description

Part I Part I-interventions will be: * Experimental intervention: Application of broad-spectrum sunscreens with a low, medium, and high Sun Protection Factor (SPF) in random order to uninvolved skin areas prior to standardized photoprovocation. * Control intervention: Intra-individual application of vehicle in random order; standardized photoprovocation of vehicle treated and untreated areas. Part II Part II-interventions will be: * Experimental intervention: Application of a broad-spectrum sunscreen with a high SPF to uninvolved skin areas prior to UV irradiation. * Control intervention: UV irradiation of untreated areas.

Conditions

• Cutaneous Lupus Erythematosus

Interventions

Type	Name	Description
OTHER	UV A and B irradiation	UV irradiation

Timeline

• Start date: 2009-11-01
• Primary completion: 2011-09-01
• Completion: 2012-11-01
• First posted: 2010-06-17
• Last updated: 2016-03-09

Locations

1 site across 1 country: Germany