Trials / Completed
CompletedNCT01146223
Biomarkers in Bone Marrow Samples From Patients With Acute Promyelocytic Leukemia
Observational - WT-1's Role in Leukemogenesis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 10 (actual)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
This research study is studying biomarkers in patients with acute promyelocytic leukemia. Studying samples of bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and about biomarkers related to cancer.
Detailed description
OBSERVATIONAL STUDY MODEL: Case-only TIME PERSPECTIVE: Retrospective BIOSPECIMEN RETENTION: Samples With DNA BIOSCPECIMEN DESCRIPTION: Bone marrow STUDY POPULATION DESCRIPTION: Primary Care Clinic SAMPLING METHOD: Non-Probability Sample PRIMARY OBJECTIVES: I. To measure WT1 and VEGF-1 expression in patients with acute promyelocytic leukemia. OUTLINE: This is a multicenter study. Patient mRNA samples from diagnosis are analyzed via quantitative PCR to measure WT1 and VEGF-1 expression.
Conditions
- Adult Acute Myeloid Leukemia
- Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)
- Adult Acute Promyelocytic Leukemia (M3)
- Childhood Acute Promyelocytic Leukemia (M3)
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | laboratory biomarker analysis | Correlative studies |
Timeline
- Start date
- 2009-09-01
- Primary completion
- 2011-06-01
- Completion
- 2011-06-01
- First posted
- 2010-06-17
- Last updated
- 2015-05-07
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT01146223. Inclusion in this directory is not an endorsement.