Trials / Terminated
TerminatedNCT01144520
Leukocyte Dysfunction in Diabetic Patients.
- Status
- Terminated
- Phase
- —
- Study type
- Observational
- Enrollment
- 42 (actual)
- Sponsor
- Sashwati Roy · Academic / Other
- Sex
- All
- Age
- 40 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to study impairment of white blood cell function in patients with type II diabetes.
Detailed description
Leucocytes from poorly controlled diabetes exhibit aberrant chemotaxis, increased susceptibility to bacterial infection, leukotriene production, lysosomal enzyme release, proinflammatory cytokine expression and production of reactive oxygen species. Aberrant glucose concentration in diabetics affects functions of peripheral blood system as well as the immune system leading to impaired host defense. Impaired wound healing is a serious complication associated with diabetes. We hypothesized that impairment in leukocyte function results in dysfunctional inflammatory response in diabetic wounds. The proposed studies focus on characterizing mechanisms that will improve our understanding of the dysfunctional inflammatory response resulting in non-healing chronic wounds in diabetics.
Conditions
Timeline
- Start date
- 2010-03-01
- Primary completion
- 2018-12-01
- Completion
- 2018-12-01
- First posted
- 2010-06-15
- Last updated
- 2021-11-22
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT01144520. Inclusion in this directory is not an endorsement.