NCT01139463

Study of Blood Lactate Levels in Patients Treated With Antipsychotics

Blood Lactate Levels in Patients Treated With Typical or Atypical Antipsychotics

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: University of Split · Academic / Other
• Sex: Male
• Age: 20 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Blood lactate levels in patients receiving typical or atypical antipsychotics have not been described in the literature. The goal of this study is to assess the dynamics of lactate levels in the blood from typical or atypical antipsychotics not confounded by prior antipsychotic treatments, the investigators conducted a prospective study of lactate levels in patients receiving antipsychotic medication. The investigators hypothesized that 6 months of treatment with haloperidol or olanzapine would result in a change in blood lactate levels and extrapyramidal side effects.

Detailed description

The aim of this study was to compare the blood lactate levels in patients receiving typical or atypical antipsychotics. Subjects included sixty patients with psychotic disorder were assigned to treatment for 6 months with haloperidol (typical antipsychotic), N=30 or olanzapine (atypical antipsychotic), N=30. Blood lactate levels, other metabolic parameters, and scores on the extrapyramidal symptom rating scale (ESRS) were assessed.

Conditions

• Movement Disorders
• Lactic Acidosis

Interventions

Type	Name	Description
DRUG	Haloperidol or olanzapine	Haloperidol tablet - 5 mg twice daily (morning and evening) by mouth Olanzapine tablet - 5 mg twice daily (morning and evening) by mouth

Timeline

• Start date: 2008-06-01
• Primary completion: 2009-10-01
• Completion: 2009-10-01
• First posted: 2010-06-08
• Last updated: 2010-06-08

Locations

1 site across 1 country: Croatia