NCT01139164

Allogeneic Hematopoietic Stem Cell Transplantation With Reduced Intensity Pre-transplant Conditioning for the Treatment of High-risk Hematological Malignancies (V3)

Allogeneic Hematopoietic Stem Cell Transplantation With Reduced-Intensity Pre-Transplant Conditioning for the Treatment of High-Risk Hematological Malignancies

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 78 (actual)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 1 Year – 75 Years
• Healthy volunteers: Not accepted

Summary

This is study is for patients that have been diagnosed with high-risk hematological malignancies. The main purpose of this study is to confirm previously published results of stem cell transplantation with reduced intensity pre-transplant conditioning. Patients will be assigned to 1 of 3 regimens depending on the patient's diagnosis. Participants will be followed by the transplant team for the remainder of the patient's life. Patient's will visit MUSC daily, then visits will be reduced to frequent visits for up to 6 months. After 6 months, the visits will be reduced more depending on the patient's condition.

Conditions

• Hematological Malignancies

Interventions

Type	Name	Description
DRUG	Regimen A	Chronic Lymphocytic Leukemia/ Chronic Prolymphocytic Leukemia, Multiple Myeloma.
DRUG	Regimen B	Other malignancies not addressed in A or C
DRUG	Regimen C	B-Cell Lymphomas

Timeline

• Start date: 2010-06-01
• Primary completion: 2014-09-01
• Completion: 2015-12-01
• First posted: 2010-06-08
• Last updated: 2018-07-11
• Results posted: 2016-03-10

Locations

1 site across 1 country: United States