NCT01138969

Efficacy of Proton Pump Inhibitor in Prevention of Clopidogrel-related Peptic Ulcer

Efficacy of Proton Pump Inhibitor in Prevention of Clopidogrel-related Peptic Ulcer and Gastrointestinal Bleeding

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 165 (actual)
• Sponsor: Kaohsiung Veterans General Hospital. · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Proton Pump Inhibitors (PPI) can prevent the recurrence of peptic ulcer in clopidogrel users.

Detailed description

The aim of the prospective, randomized study is to investigate the efficacy of PPI in prevention of ulcer recurrence for clopidogrel users. We plan to enroll 300 clopidogrel users without baseline gastroduodenal ulcer at initial endoscopy. The patients will be randomly assigned to receive either (1) esomeprazole (20 mg qd) plus clopidogrel or (2) clopidogrel treatment alone for 6 months. The ulcer recurrence rate between the treatment groups will be compared.

Conditions

• Peptic Ulcer

Interventions

Type	Name	Description
DRUG	esomeprazole	esomeprazole 20 mg qd for 6 months

Timeline

• Start date: 2008-08-01
• Primary completion: 2012-12-01
• Completion: 2012-12-01
• First posted: 2010-06-08
• Last updated: 2015-09-09
• Results posted: 2013-02-04

Locations

1 site across 1 country: Taiwan