Trials / Completed
CompletedNCT01138332
Biomarkers in Young Patients With Acute Myeloid Leukemia
Stat3 Signaling Pathway Aberrancies in Pediatric AML
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 20 (actual)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- 21 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in tissue samples from young patients with acute myeloid leukemia.
Detailed description
OBJECTIVES: * Determine the frequency of ligand-independent phosphorylation of Stat3 in a small cohort of samples from pediatric patients with acute myeloid leukemia including, but not limited to, samples known to express mutated c-kit. * Measure the level of Stat3 phosphorylation in these samples after stimulation of three key cytokine receptors expressed on hematopoietic cells IL-6R, G-CSFR, and c-kit. OUTLINE: Cryopreserved samples are analyzed for levels of various components of the Stat3 pathway via western blotting.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | western blotting | |
| OTHER | laboratory biomarker analysis |
Timeline
- Start date
- 2009-09-01
- Primary completion
- 2010-03-01
- Completion
- 2010-03-01
- First posted
- 2010-06-07
- Last updated
- 2015-05-06
Source: ClinicalTrials.gov record NCT01138332. Inclusion in this directory is not an endorsement.