NCT01137357

Probiotics for Reduction Of Markers In Subjects With Allergy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Rijnstate Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

In vitro studies reveal immunomodulatory effects of probiotic bacteria that are strain-dependent. Differential immunomodulatory in vitro capacities can not be extrapolated directly to in vivo efficacy. Thus, in vitro screening should be followed by comparative analysis of the selected immunomodulatory probiotic strains in an in vivo setting. Birch pollen allergy is one of the most common forms of respiratory allergy in European countries, and recognized by a Th2-skewed immune system. Five Lactobacillus strains will be evaluated for their immunomodulatory properties in birch pollen sensitive subjects outside the hay fever season. A double-blind placebo-controlled parallel study will be performed in which subjects with a proven birch pollen allergy will consume one of 5 different probiotic yoghurts containing 4 L. plantarum strains and 1 L. casei strain or a placebo yoghurt. Blood samples are collected at the start and after 4 weeks. Immune parameters are determined in serum and peripheral blood mononuclear cell cultures (hPBMC) derived from these subjects.

Conditions

• Hay Fever
• Birch Pollen Allergy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Yoghurt with L. plantarum strain	Intake of yoghurt during 4 weeks
DIETARY_SUPPLEMENT	Yoghurt with L.casei	Intake of yoghurt during 4 weeks
DIETARY_SUPPLEMENT	Yoghurt with L. plantarum strain	Intake of yoghurt during 4 weeks
DIETARY_SUPPLEMENT	Yoghurt with L. plantarum strain	Yoghurt with L. plantarum strain
DIETARY_SUPPLEMENT	Yoghurt with L. plantarum strain	Intake of yoghurt during 4 weeks
DIETARY_SUPPLEMENT	Yoghurt	Intake of yoghurt during 4 weeks

Timeline

• Start date: 2008-11-01
• Primary completion: 2008-12-01
• Completion: 2008-12-01
• First posted: 2010-06-04
• Last updated: 2010-06-04

Locations

1 site across 1 country: Netherlands