NCT01136564

Reno- and Vascular Protective Effect of a Vitamin-D-analogue in Moderate to Severe Chronic Kidney Disease

Reno- and Vascular Protective Effect of a Low-calcemic Vitamin-D-analogue (Paricalcitol) in Stage III-IV Chronic Kidney Disease

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Erling Bjerregaard Pedersen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Recently it has been documented that vitamin D has important functions in the human body that are unrelated to its primary effects in calcium homeostasis and bone mineralization. In clinical studies, paricalcitol - a low-calcemic vitamin D analogue - has been shown to decrease proteinuria, a marker of disease progression and cardiovascular risk in patients with chronic kidney disease (CKD). The purpose of this study is to investigate the effect of a paricalcitol on renal and cardiovascular variables in patients with moderate to severe CKD.

Conditions

• Chronic Kidney Disease

Interventions

Type	Name	Description
DRUG	Zemplar	2 capsules of 1 microgram daily
DRUG	Placebo	2 capsules daily

Timeline

• Start date: 2010-07-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2010-06-03
• Last updated: 2012-01-25

Locations

1 site across 1 country: Denmark