NCT01135888

Short Term Effects and Risks of Physical Exercise in Subjects With Hypohidrotic Ectodermal Dysplasia

Short Term Effects and Risks of Physical Exercise in Subjects With Hypohidrotic Ectodermal Dysplasia (Christ-Siemens-Touraine Syndrome)

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 28 (actual)
• Sponsor: University Hospital Erlangen · Academic / Other
• Sex: Male
• Age: 7 Years – 18 Years
• Healthy volunteers: Accepted

Summary

Because of their lack of sweat glands individuals with hypohidrotic ectodermal dysplasia (HED) are at particular risk of life-threatening hyperthermia during exercise in a warm environment. In this study, the effects of physical exercise are investigated in boys and male adolescents with X-chromosomally inherited HED as well as age-matched controls, who undergo standardized exertion on a bicycle ergometer at ambient temperatures of 25°C and 30°C. Body core temperature during and after ergometry, heart rate, performance, and serum lactate as a marker of metabolic stress are measured. Subjects with HED are expected to show an endangering rise of body temperature in connection with physical exercise. To clarify, whether novel cooling devices may reduce the likelihood of overheating, the effects of such devices are evaluated at 30°C.

Conditions

• X-Linked Hypohidrotic Ectodermal Dysplasia
• Exercise-induced Rise of Body Temperature

Interventions

Type	Name	Description
DEVICE	Skin cooling devices	Cooling vest and cooling bandana

Timeline

• Start date: 2009-04-01
• Primary completion: 2010-02-01
• Completion: 2010-02-01
• First posted: 2010-06-03
• Last updated: 2021-08-19

Locations

1 site across 1 country: Germany