Trials / Completed
CompletedNCT01132560
Biomarkers in Tissue Samples From Patients With Ductal Breast Carcinoma in Situ
A Correlative Science Study for ECOG E5194
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 500 (actual)
- Sponsor
- ECOG-ACRIN Cancer Research Group · Network
- Sex
- Female
- Age
- 18 Years – 120 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in tissue samples from patients with ductal breast carcinoma in situ.
Detailed description
OBJECTIVES: * To validate the prognostic utility of a new ductal breast carcinoma in situ (DCIS) genomic score and the Oncotype DX Recurrence Score® assay in tissue samples from patients with DCIS enrolled on clinical trial ECOG-E5194. OUTLINE: RNA extracted from archived tissue samples are analyzed for gene expression profile by Oncotype DX Recurrence Score® assay (a reverse transcriptase-PCR-based assay).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | RNA analysis | |
| GENETIC | gene expression analysis | |
| GENETIC | reverse transcriptase-polymerase chain reaction | |
| OTHER | laboratory biomarker analysis |
Timeline
- Start date
- 2010-03-05
- Primary completion
- 2010-04-05
- Completion
- 2010-04-05
- First posted
- 2010-05-28
- Last updated
- 2017-05-17
Source: ClinicalTrials.gov record NCT01132560. Inclusion in this directory is not an endorsement.