NCT01129687

Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy

Multicenter Prospective Analysis of Treatment Outcome in Patients With Large Acoustic Neuromas

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 157 (actual)
• Sponsor: Stanford University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators study is to investigate safety and efficacy of performing a planned incomplete removal of large acoustic neuroma tumors to decrease surgical morbidity and yet avoid tumor recurrence by post-operative radiation therapy.

Detailed description

The current standard treatment of a large tumor of the balance nerve (acoustic neuroma or vestibular schwannoma) is surgical resection. Complete removal of such tumor is associated with significant risks of hearing loss and facial paralysis whereas incomplete removal of the tumor is associated with significant risks of regrowth. Stereotactic radiation is a well accepted therapy aiming at stopping the growth of smaller acoustic neuromas before their sizes become large enough to cause problems. The purpose of our study is to determine whether the combination of subtotal resection followed by stereotactic radiation of the remnant can control large acoustic neuromas without the significant risks associated with complete resection.

Conditions

• Neuroma, Acoustic

Interventions

Type	Name	Description
PROCEDURE	Microsurgery	Patient would under to total, near-total, or subtotal resection of tumor
PROCEDURE	Stereotactic radiation therapy	Patient who has sign of growth of tumor remnant would undergo this treatment

Timeline

• Start date: 2005-03-01
• Primary completion: 2022-05-08
• Completion: 2022-05-08
• First posted: 2010-05-25
• Last updated: 2022-05-10

Locations

9 sites across 1 country: United States