NCT01128816

Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure

A Multi-Centre, Randomized Study to Assess the Effects of Adaptive Servo Ventilation (ASV) on Survival and Frequency of Hospital Admissions in Patients With Heart Failure (HF) and Sleep Apnea (SA)-The ADVENT-HF Trial

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 732 (actual)
• Sponsor: Toronto Rehabilitation Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Sleep Apnea (SA) is a disorder that causes pauses in breathing during sleep that expose the heart to oxygen deprivation. It is common in patients with heart failure (HF) where it is associated with increased risk of hospitalizations and death. It is not known however whether treating SA reduces these risks. This study is looking at whether a respiratory device known as Adaptive Servo Ventilation (ASV) can reduce the rate of cardiovascular hospitalizations and death in subjects with HF and SA. Study subjects will randomly receive either their regular medications OR their regular medications plus ASV. They will be followed for approximately 5 years and information relevant to their health will be collected and compared.

Conditions

• Sleep Apnea
• Heart Failure

Interventions

Type	Name	Description
DEVICE	Adaptive Servo Ventilation	BiPAP autoSV ADVANCED device worn nightly during sleep

Timeline

• Start date: 2010-05-01
• Primary completion: 2022-03-31
• Completion: 2022-03-31
• First posted: 2010-05-24
• Last updated: 2022-11-22

Locations

49 sites across 9 countries: United States, Brazil, Canada, France, Germany, Italy, Japan, Spain, United Kingdom