NCT01121003

Effects of Fructose and Exercise on Hepatic Lipid Metabolism

Effects of a Weight Maintenance, High Fructose Diet and of Exercise on Hepatic Lipid Metabolism

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 8 (estimated)
• Sponsor: University of Lausanne · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

8 healthy male volunteers will be studied each on 3 occasions, ie * after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity * after 4 days on a weight maintenance diet containing 30% fructose + low physical activity * after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured

Conditions

• Metabolism

Interventions

Type	Name	Description
BEHAVIORAL	weight maintenance, low sugar diet
BEHAVIORAL	weight maintenance, high fructose diet
BEHAVIORAL	weight maintenance, high fructose diet+ exercise

Timeline

• Start date: 2010-05-01
• Primary completion: 2011-10-01
• Completion: 2011-10-01
• First posted: 2010-05-11
• Last updated: 2011-10-19

Locations

1 site across 1 country: Switzerland