NCT01119196

The Measurement of Insulin Resistance in Peritoneal Dialysis Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Vanderbilt University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The goal of this study is to examine the relevance of insulin resistance in peritoneal dialysis (PD) patients as well as the means to improve this metabolic derangement. We will do so through a prospective randomized study using Icodextrin as an alternate dialysate solution to routine glucose-based dialysate. We hypothesize that (1) the glucose loading associated with PD leads to impairment in insulin sensitivity, (2) the degree of insulin resistance is dependent on the basal metabolic state (fasting versus stimulated), and (3) the replacement of conventional dialysate with glucose-sparing dialysate preparations will improve insulin resistance and associated metabolic disturbances in PD patients.

Conditions

• End Stage Renal Disease

Interventions

Type	Name	Description
OTHER	Icodextrin dialysate	use of alternate SOC dialysate

Timeline

• Start date: 2010-09-01
• Primary completion: 2015-01-01
• Completion: 2015-01-01
• First posted: 2010-05-07
• Last updated: 2016-09-26

Locations

1 site across 1 country: United States