NCT01112878

Oral Clonidine & Gabapentin: Improving Recovery and Pain Management After Outpatient With Major Orthopedic Surgery

Randomized, Double-Blinded, Placebo-controlled Study to Evaluate the Analgesic Efficacy of Oral Clonidine and Gabapentin as Part of a Multi-modal Analgesic Regimen for Preventing Pain After Arthroscopic Shoulder or Knee Surgery

• Status: Withdrawn
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Cedars-Sinai Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research is to investigate the non-opioid (non-narcotic) pain-relieving medications clonidine and gabapentin to see if they decrease the amount of opioid pain medications needed after surgery, thereby reducing opioid-related side effects, and time required to return to normal activities of daily living after surgery.

Conditions

• Shoulder Arthroscopy
• Knee Arthroscopy

Interventions

Type	Name	Description
DRUG	Sugar pill	Dosage form: capsule, by mouth Dosage: not applicable Frequency and Dosage: * once in the preoperative holding area and once before discharge from PACU * continuation of 1 capsule twice daily with meals, 1 to 4 days after surgery.
DRUG	Gabapentin	Dosage form: capsule, by mouth Dosage: 600 mg Frequency and duration: * once in the preoperative holding area and once before discharge from PACU * continuation of 1 capsule twice daily with meals, 1 to 4 days after surgery.
DRUG	Clonidine	Dosage form: capsule, by mouth Dosage: 0.2 mg Frequency and duration: * once in the preoperative holding area and once before discharge from PACU * continuation of 1 capsule twice daily with meals, 1 to 4 days after surgery.

Timeline

• Start date: 2015-06-01
• Primary completion: 2015-06-01
• Completion: 2015-06-01
• First posted: 2010-04-29
• Last updated: 2015-09-14

Locations

1 site across 1 country: United States