NCT01112436

The Effect of Periarticular Multi-Drug Regimen on Pain After Partial Hip Replacement

The Effect of Periarticular Injection of Multi-drug Regimen on Pain in Patient Receiving Partial Hip Replacement:Randomized Prospective Study.

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 258 (estimated)
• Sponsor: Chung-Ang University Hosptial, Chung-Ang University College of Medicine · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This prospective randomized study aims to evaluate the effectiveness of periarticular multi-drug regimen injection on the relief of pain in patients undergoing partial hip replacement. Total 258 patients will be randomized into one of two groups (groupC or groupI) based on Excel number generation. Patients in group C will receive no medication intraoperatively, and patients in group I will receive oral oxycodone and celecoxib preoperatively and a periarticular injection of multi-drug regimen during operation. Visual analogue scale pain scores, fentanyl consumption and the frequency at which patients pushed the button (FPB) of a patient-controlled analgesia system will be recorded at 1, 4, 7 postoperative day.

Detailed description

Patients in group I will receive oxycodone SR 10 mg, and celecoxib 200 mg with 10 ml of water 1 hour before surgery. And patients in group I will receive periarticular injection of 50 ml solution which contains ropivacaine 15 mg, epinephrine 0.3 mg, cefmetazole 1000mg, ketorolac 30 mg and morphine HCL 10mg before closure of surgical wound. Patients in group C will receive no medication.

Conditions

• Femoral Neck Fracture

Interventions

Type	Name	Description
DRUG	periarticular injection of multidrug regimen	periarticular injection of combination of ropivacaine 15 mg, epinephrine 0.3mg, cefmetazole 1000mg, ketorolac 30mg, morphine HCL 10 mg
DRUG	none of medication preoperatively and intraoperatively	Patients in Group C wil receive none of medication preoperatively and intraoperatively

Timeline

• Start date: 2010-05-01
• Primary completion: 2012-04-01
• Completion: 2012-04-01
• First posted: 2010-04-28
• Last updated: 2011-06-27

Locations

1 site across 1 country: South Korea