NCT01111994

Efficacy & Safety of Clindamycin and Tretinoin in Acne

Efficacy & Safety of Clindamycin Phosphase 1.2% and Tretinoin 0.025% Gel vs. Vehicle for the Treatment of Acne and Acne-Induced Post Inflammatory Hyperpigmentation in Patients With Skin of Color

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Callender Center for Clinical Research · Academic / Other
• Sex: All
• Age: 12 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is ascertain the efficacy and safety of Clindamycin Phosphate 1.2% and Tretinoin 0.025% in the treatment of Acne and Post Inflammatory Hyperpigmentation in patients with skin of color.

Detailed description

Acne is a chronic disorder of the pilosebaceous glands characterized by inflammatory papules, pustules, opened and closed comedones, cysts and nodules. Post inflammatory hyperpigmentation is a condition in which an inflammation from a disease such as acne, trauma, or abrasion results in areas of the skin with increased melanin content compared to the surrounding skin. There are several treatments available for acne, which include benzoyl peroxide,antibiotics (topical or oral), and topical retinoids (tretinoin, tazarotene, adapalene). Combination therapy, such as topical retinoid and clindamycin, has been shown to be more effective than monotherapy in addressing all pathogenic factors of acne.

Conditions

• Acne

Interventions

Type	Name	Description
DRUG	Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel	Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel QD for 3 months

Timeline

• Start date: 2009-11-01
• Primary completion: 2010-03-01
• Completion: 2010-04-01
• First posted: 2010-04-28
• Last updated: 2010-05-20

Locations

2 sites across 1 country: United States