NCT01108107

Neoadjuvant Treatment of Colon Cancer

Neoadjuvant Chemotherapy and Biological Treatment for Patients With Locally Advanced Colon Cancer

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 76 (actual)
• Sponsor: Vejle Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will investigate * the effect of preoperative combination chemotherapy in patients with locally advanced colon cancer with mutation in the KRAS, BRAF or PIK3CA gene * the effect of preoperative combination chemotherapy in combination with biological treatment in patients without mutation in the KRAS, BRAF or PIK3CA gene.

Conditions

• Colon Cancer

Interventions

Type	Name	Description
DRUG	Oxaliplatin	130 mg/m2 intravenously on day 1 of a 3-weekly cycle
DRUG	Capecitabine	2000 mg/m2/day (tablets) on day 1 and 14 of a 3-weekly cycle
DRUG	Oxaliplatin	130 mg/m2 intravenously on day 1 of a 3-weekly cycle
DRUG	Capecitabine	2000 mg/m2/day (tablets) on day 1 and 14 of a 3-weekly cycle
BIOLOGICAL	Panitumumab	9 mg/kg intravenously on day 1 of a 3-weekly cycle

Timeline

• Start date: 2010-04-01
• Primary completion: 2013-09-01
• Completion: 2015-03-01
• First posted: 2010-04-21
• Last updated: 2015-05-21

Locations

3 sites across 1 country: Denmark