NCT01106937

Factor XIII and Pulmonary Embolism in Neurosurgical Patients

Risk Factors for Perioperative Pulmonary Embolism in Neurosurgical Patients in Respect of Factor XIII Activity

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 130 (estimated)
• Sponsor: Ludwig-Maximilians - University of Munich · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Two studies (Gerlach et al. 2000; Gerlach et al. 2002) described the impact of factor XIII on the risk of prospective hemorrhage for patients undergoing craniotomy. Since then, factor XIII is measured and substituted in various centers. Few reports support the idea of factor XIII being involved in the formation of deep venous thrombosis and pulmonary embolism. In this prospective observational study, patients undergoing craniotomy for brain tumors or vascular lesions are investigated concerning the incidence of postoperative pulmonary embolism in respect of possible risk factors (factor XIII activity levels, standard coagulation parameters, tumor entity, blood loss).

Conditions

• Brain Tumor
• Vascular Lesion
• Factor XIII Deficiency
• Pulmonary Embolism

Timeline

• Start date: 2007-10-01
• Primary completion: 2010-12-01
• Completion: 2010-12-01
• First posted: 2010-04-20
• Last updated: 2010-04-20

Locations

1 site across 1 country: Germany