NCT01105351

Effect of Folic Acid on Primary Folate Forms in Relation to MTHFR

Effect of Mild Increase in Folic Acid Intake on the Distribution of Folate Forms in Relation to a Common Polymorphism in One Folate Catabolising Enzyme

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Universität des Saarlandes · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

The common polymorphism in MTHFR gene (C677T) has a significant effect on (6S)-5-CH3-H4folate after folic acid supplementation. For example, post supplementation differences in (6S)-5-CH3-H4folate between CC and TT are above 30%.

Detailed description

The investigators aim to test the effect of low doses of folic acid with or without B6 and B12 on folate forms in relation to polymorphisms in folate catabolising enzymes in elderly people. Our hypothesis is that differences in folate forms after folic acid supplementation might be due to polymorphisms in folate catabolising enzymes. Therefore, folic acid might be retained by people with certain genotypes.

Conditions

• the Effect of MTHFR C677T on Folate Metabolism

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	folic acid plus B6 and B12	folic acid 400 µg plus vitamin B12 plus B6
DIETARY_SUPPLEMENT	folic acid	folic acid 400 µg

Timeline

• Start date: 2010-06-01
• Primary completion: 2012-12-01
• Completion: 2013-12-01
• First posted: 2010-04-16
• Last updated: 2018-05-14

Locations

1 site across 1 country: Germany