NCT01100515

Hyperbaric Oxygen Therapy for Acute Domestic Carbon Monoxide (CO) Poisoning

Phase 3 Study of Hyperbaric Oxygen Therapy in Non-Comatose Patients With Acute Domestic Carbon Monoxide Poisoning

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 179 (actual)
• Sponsor: University of Versailles · Academic / Other
• Sex: All
• Age: 15 Years
• Healthy volunteers: Not accepted

Summary

Carbon monoxide poisoning still places a burden on the healthcare system worldwide. While oxygen therapy is the cornerstone treatment, the role and practical modalities of hyperbaric oxygen therapy (HBO) remain controversial. This study aimed at comparing one session of HBO at 2 absolute atmosphere followed by 4 hours of normobaric oxygen therapy to 6 hours of normobaric oxygen therapy in adult victims of acute domestic carbon monoxide poisoning and without coma.

Conditions

• Carbon Monoxide Poisoning

Interventions

Type	Name	Description
OTHER	normobaric oxygen therapy	oxygen therapy was delivered via a full face mask at high flow to achieve 100% of inspired oxygen fraction
OTHER	Hyperbaric oxygen therapy	Hyperbaric oxygen therapy was delivered in a hyperbaric chamber, pressurized at 2 absolute atmosphere (1 hour plateau) and the patient breathed high oxygen concentration via a full face mask followed by 4 hours of normobaric oxygen therapy

Timeline

• Start date: 1989-10-01
• Primary completion: 2000-01-01
• Completion: 2000-02-01
• First posted: 2010-04-09
• Last updated: 2010-04-09

Locations

1 site across 1 country: France