NCT01099995

Hyperbaric Oxygen Therapy for Comatose Patients With Acute Carbon Monoxide Poisoning

Phase 3 Study of Hyperbaric Oxygen Therapy for Comatose Patients With Acute Domestic Carbon Monoxide Poisoning

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 170 (actual)
• Sponsor: University of Versailles · Academic / Other
• Sex: All
• Age: 15 Years
• Healthy volunteers: Not accepted

Summary

Carbon monoxide poisoning still places a burden on the healthcare system worldwide. While oxygen therapy is the cornerstone treatment, the role and practical modalities of hyperbaric oxygen therapy (HBO) remain controversial. This study aimed at comparing two sessions of HBO at 2 absolute atmosphere and one session of HBO at 2 absolute atmosphere followed by 4 hours of normobaric oxygen therapy in comatose adult victims of acute domestic carbon monoxide poisoning.

Conditions

• Carbon Monoxide Poisoning

Interventions

Type	Name	Description
OTHER	Hyperbaric oxygen therapy	one dive at 2 absolute atmosphere (1-hour plateau) with 30 min time for compression and decompression - oxygen was delivered via a full face mask at high concentration to achieve a 100% inspired fraction of oxygen or via mechanical ventilation
OTHER	hyperbaric oxygen therapy	two dives at 2 absolute atmosphere (1-hour plateau) with 30 min of compression and 30 min of decompression - oxygen being delivered via a full face mask at 100% inspired oxygen fraction or via mechanical ventilation

Timeline

• Start date: 1989-10-01
• Primary completion: 2000-01-01
• Completion: 2000-02-01
• First posted: 2010-04-08
• Last updated: 2010-04-08

Locations

1 site across 1 country: France