NCT01097733

Dual-Source Computed Tomography to Improve Prediction of Response to Cardiac Resynchronization Therapy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 38 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cardiac Resynchronization Therapy (CRT) is a widely accepted treatment that has led to improved clinical outcomes for patients with refractory congestive heart failure (CHF), systolic dysfunction, and wide QRS duration. However, it requires implantation of an expensive device ($30,000) and about 1/3 of patients do not have clinical improvement. Inadequate amounts of LV dyssynchrony or suboptimal lead placement may limit clinical response. Dual-Source computed tomography (DSCT) allows for subtle detection during myocardial contraction for assessing LV dyssynchrony, and can also assess coronary venous anatomy and scar burden. Thus DSCT may be the ideal noninvasive modality to predict response to CRT.

Conditions

• Heart Failure - NYHA II - IV
• Wide QRS Complex

Interventions

Type	Name	Description
OTHER	Randomization of Pre-knowledge of CT coronary venography

Timeline

• Start date: 2009-02-01
• Primary completion: 2012-01-01
• Completion: 2012-01-01
• First posted: 2010-04-02
• Last updated: 2022-10-03

Locations

1 site across 1 country: United States