NCT01097356

The Effect of Probiotics on the Clearance of the Human Papillomavirus and on Cytological Lesions Caused by the Virus

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Universiteit Antwerpen · Academic / Other
• Sex: Female
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Aim: In this project proposition the investigators would like to examine the effect of immune modulation by probiotics on the clearance of HPV-infections. This study provides a model for viral infection but also for cancer precursors. This would be an excellent model (and the only possible short-term model) to examine an effect on cancer precursors. Cancer precursors (cytological abnormalities such as L-SIL) are a scientifically accepted surrogate endpoint for cervical cancer, for example in HPV-vaccine studies. Research question: Does daily intake of probiotics lead to a better immune-response in HPV-infected women, i.e. does it facilitate clearance of the virus and/or regression of cytological lesions?

Conditions

• HPV-related Cytological Abnormalities on PAP Smear (LSIL)

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	probiotic drinkers	HPV+, LSIL patients in this arm will drink the probiotic study drink for a period of 6 months

Timeline

• Start date: 2010-04-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2010-04-01
• Last updated: 2021-10-01

Locations

1 site across 1 country: Belgium