NCT01097226

Bioavailability and Vascular Effects of Apple Polyphenols

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Quadram Institute Bioscience · Academic / Other
• Sex: All
• Age: 45 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The main purpose of this study is to determine the oral bioavailability of flavanols (polyphenolic compounds) from apple granules and an apple extract delivered in a water based beverage at two different doses. We will also investigate the effects of apple flavanols on nitric oxide production.

Detailed description

This study is a randomized four phase crossover trial investigating the bioavailability of apple flavanols and the effects on nitric oxide products, a surrogate marker for changes in endothelial function. Each test phase will comprise a 3 day period of intervention which will be identical in nature (except for the test product consumed) and separated by a minimum of 1 week. On days 1-3 of each test phase volunteers will consume a low flavanol diet. After consumption of the test product on the morning of day 2, blood and urine samples will be collected at regular intervals for the next 24h.

Conditions

• Healthy

Interventions

Type	Name	Description
OTHER	Apple extract delivering 70 mg epicatechin	Delivered as a flavoured water based beverage
OTHER	Apple extract delivering 140 mg epicatechin	Delivered as a flavoured water based beverage
OTHER	Apple granules delivering 70 mg epicatechin	Delivered as a puree
OTHER	Water delivering no epicatechin	Delivered as flavoured water

Timeline

• Start date: 2010-04-01
• Primary completion: 2010-12-01
• Completion: 2011-06-01
• First posted: 2010-04-01
• Last updated: 2013-03-06

Locations

1 site across 1 country: United Kingdom