NCT01095211

B-vitamins Treatment for Improvement of Cognitive Function

Effect of B-Vitamins on Cognitive Function in Elderly People

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 79 (actual)
• Sponsor: Universität des Saarlandes · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Not accepted

Summary

Observation studies documented a correlation between plasma concentrations of homocysteine and cognitive decline with age. The study hypothesis was that high doses of B-vitamins (as effective homocysteine lowering treatment) can improve cognitive function in elderly people.

Detailed description

We performed a treatment with therapeutic doses of B-vitamins (folic acid, cobalamin, vitamin B6) for 45 days. We collected blood and tested the concentrations of the metabolic markers in blood at start, 3 weeks later and at the end. Cognitive function was tested at start and at the end.

Conditions

• Cognitive Function
• Metabolic Improvements

Interventions

Type	Name	Description
DRUG	B-vitamin complex	5 mg Folic acid, plus 1 mg cyanocobalamin and 40 mg vitamin B6) oral/ day. The placebo capsule contained 400 mg of mannitol: aerosil (99.5: 0.5). In addition, 1 mg/s.c cyanocobalamin daily

Timeline

• Start date: 2003-01-01
• Primary completion: 2005-09-01
• Completion: 2009-12-01
• First posted: 2010-03-30
• Last updated: 2018-05-11

Locations

1 site across 1 country: Germany