NCT01090518

Cortisol Augmentation of a Psychological Treatment in Warfighters With Post Traumatic Stress Disorder (PTSD)

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (estimated)
• Sponsor: Bronx VA Medical Center · Federal
• Sex: All
• Age: 18 Years – 89 Years
• Healthy volunteers: Not accepted

Summary

This study seeks to examine the efficacy of hydrocortisone administration in the augmentation of the therapeutic effects of Prolonged Exposure (PE) therapy, an empirically tested treatment shown to be effective in the the treatment of posttraumatic stress disorder (PTSD). The augmentation builds on both the translation of neuroscience findings demonstrating the effects of glucocorticoids (GCs) on learning, and on empirical clinical findings from other investigators demonstrating beneficial effects of GCs in reducing traumatic memories in trauma-exposed persons.

Conditions

• PTSD

Interventions

Type	Name	Description
BEHAVIORAL	Prolonged Exposure therapy	10 weekly sessions
DRUG	Hydrocortisone	30mg 20 minutes prior to each PE session including imaginal exposure (8 total)
BEHAVIORAL	Prolonged Exposure therapy	10 weekly sessions

Timeline

• Start date: 2010-02-01
• Primary completion: 2013-11-01
• First posted: 2010-03-22
• Last updated: 2013-02-05

Locations

1 site across 1 country: United States