NCT01089985

Use of Autologous Serum Eye-drops as Tears in Patients With Recalcitrant Dry Eye

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Singapore National Eye Centre · Other Government
• Sex: All
• Age: 21 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to examine the efficacy and safety of autologous serum eye drops in people with recalcitrant dry eye.

Detailed description

A group of selected dry eye patients from the Singapore National Eye Centre who have exhausted the usual treatment options (lubricants, topical immunosuppressive and punctal occlusion) and not keen for tarsorrhaphy will be recruited. After informed consent, they will undergo plasmapheresis and start on daily autologous serum eyedrops for a period of 4 months. Clinical monitoring for standard dry eye parameters such as punctate corneal keratitis, Schirmers testing, tear break up time as well as severity and frequency of dry eye symptoms will be conducted. Tear inflammatory proteins captured on Schirmers paper pre and post treatment will be analysed as well.

Conditions

• Xerophthalmia

Interventions

Type	Name	Description
DRUG	Autologous serum eyedrops	3 times a day for the duration of the study

Timeline

• Start date: 2010-07-01
• Primary completion: 2011-12-01
• Completion: 2011-12-01
• First posted: 2010-03-19
• Last updated: 2012-01-18

Locations

1 site across 1 country: Singapore