NCT01088256

Efficacy of Etoricoxib on Peripheral Hyperalgesia

Efficacy of Etoricoxib in Patients With Neuropathic Pain With and Without Peripheral Hyperalgesia - A Prove of Concept Trial

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Ruhr University of Bochum · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to determine the efficacy of etoricoxib on pain patients. The investigators assume that patients with neuropathic pain will have greater pain relief then patients on placebo.

Detailed description

Animal experiments analysing anti-hyperalgesic effects of Coxibs show inconsistent results due to different used dosages and varying different pain models. Theoretical the use of NSAIDs is rational, particularly of Coxibs as a part of the neuropathic pain management. But in the newest topical review, there is no valid information available about the effectiveness of these drugs in human neuropathic pain models or in patients with different underlying mechanism, e.g. with or without hyperalgesia.

Conditions

• Causalgia
• Polyneuropathy
• Postherpetic Neuralgia
• Peripheral Nerve Injury
• Radiculopathy

Interventions

Type	Name	Description
DRUG	Etoricoxib	the patients get etoricoxib 90mg for 8 days. They get one pill with 90mg per day
DRUG	placebo	patients get one pill of placebo (sugar-pill) per day for 8 days.

Timeline

• Start date: 2011-02-01
• Primary completion: 2012-08-01
• Completion: 2012-08-01
• First posted: 2010-03-17
• Last updated: 2012-08-24

Locations

1 site across 1 country: Germany