NCT01087359

Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Herlev Hospital · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

This is a double blinded, randomised, crossover study with 12 healthy men between 18 and 40 year. The design is based on 6 days: * day 1: On day time administration of LPS. * day 2: On night time administration of LPS. * day 3: On day time administration of LPS + Placebo. * day 4: On day time administration of LPS + melatonin. * day 5: On night time administration of LPS + placebo. * day 6: On night time administration og LPS + melatonin. Measuring the inflammatoric and oxidative response of LPS and the effect of melatonin compared to placebo on the endotoxaemia.

Conditions

• Human Endotoxaemia

Interventions

Type	Name	Description
DRUG	Melatonin	100 mg melatonin is tested on human endotoxaemia administrated on night and day time compared to placebo

Timeline

• Start date: 2010-06-01
• Primary completion: 2011-01-01
• Completion: 2011-02-01
• First posted: 2010-03-16
• Last updated: 2011-06-20

Locations

1 site across 1 country: Denmark