NCT01086475

D-Cycloserine and Social Skills Training in Autism Spectrum Disorders

A Randomized, Placebo-Controlled Trial of D-Cycloserine for the Enhancement of Social Skills Training in Pervasive Developmental Disorders

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 68 (actual)
• Sponsor: Indiana University · Academic / Other
• Sex: All
• Age: 5 Years – 11 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to determine the effectiveness of D-cycloserine for improving social impairment in child with pervasive developmental disorders (PDD).

Detailed description

This study will evaluate the efficacy of D-Cycloserine given 30 minutes prior to each of 10 weekly Social Skills Training Sessions for the treatment of social impairment in children (ages 5-11 years) with PDD during a randomized placebo-controlled trial. This will examine our central hypothesis that D-cycloserine will enhance learning of social skills in children with PDD's.

Conditions

• Autistic Disorder
• Asperger's Disorder
• Pervasive Developmental Disorder NOS

Interventions

Type	Name	Description
DRUG	D-cycloserine	50 mg dose administered 30 minutes prior to each of the ten Social Skill Training Sessions
DRUG	Placebo	Placebo pill administered 30 minutes prior to each of the ten Social Skill Training Sessions

Timeline

• Start date: 2010-03-01
• Primary completion: 2014-01-01
• Completion: 2014-01-01
• First posted: 2010-03-15
• Last updated: 2016-04-14
• Results posted: 2016-04-14

Locations

2 sites across 1 country: United States