NCT01081392

Inflammatory Markers in Sputum After LPS Inhalation

The Role of Inhaled Particle Size on the Inflammatory Response Induced by Endotoxin Inhalation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Centre Hospitalier Universitaire Brugmann · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of the study is to measure inflammatory biomarkers in sputum and peripheral blood in healthy volunteers after inhalation of single doses of LPS (20 mcg) administered as particles of different sizes.

Detailed description

Endotoxins are inflammatory substances present in the environment. In man, the inhalation of the lipopolysaccharride moiety (LPS) induces measurable immune responses. With an inhaled single dose of 20 micron, the inflammatory response in man is sub-clinical. During bronchoprovocation tests with allergens, the particle size determines to a large extent the intensity of the response. the response to LPS as a function of particle size is not known and will be studied in this study.

Conditions

• Inflammation

Interventions

Type	Name	Description
BIOLOGICAL	LPS	LPS 20mcg sd inhaled via nebulizer, 3 periods

Timeline

• Start date: 2010-01-01
• Primary completion: 2010-04-01
• Completion: 2010-05-01
• First posted: 2010-03-05
• Last updated: 2010-03-05

Locations

1 site across 1 country: Belgium