NCT01080963

Daptomycin as Antibiotic Prophylaxis of Sternal Wound Infections

Prospective Randomised Study of Daptomycin as Antibiotic Prophylaxis of Sternal Wound Infections After Median Sternotomy

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 650 (actual)
• Sponsor: Hannover Medical School · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to show that the incidence of sternal wound infections at day 30 after cardiac surgery is 50% lower with the additional use of Daptomycin on top of a standard antibiotic prophylaxis as compared to the standard antibiotic prophylaxis alone.

Conditions

• Wound Infection

Interventions

Type	Name	Description
DRUG	Daptomycin	one infusion of 350 mg intraoperatively after disconnection from the heart-lung machine as an add-on to standard antibiotic prophylaxis
DRUG	Cefuroxime	1500 mg intravenous 30min preoperatively during anesthesia and 1500 mg intravenous intraoperatively after disconnection from the heart-lung machine

Timeline

• Start date: 2008-11-01
• Primary completion: 2012-03-01
• Completion: 2012-03-01
• First posted: 2010-03-05
• Last updated: 2012-04-17

Locations

1 site across 1 country: Germany