NCT01079429

Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM.

Large Scale Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From Monoclonal Gammopathy of Undetermined Significance (MGUS) and Indolent Myeloma (SMM).

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 1,200 (estimated)
• Sponsor: Rennes University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to describe DNA copy number variations and gene expression profiles of bone marrow plasma cells of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). The final objective is to search for correlations with the risk of progression in order to establish a predictive model of early malignant transformation.

Conditions

• Monoclonal Gammopathy of Undetermined Significance
• Smoldering Myeloma

Interventions

Type	Name	Description
GENETIC	Genetic study of DNA copies	Gene expression profiling, DNA copy number variation

Timeline

• Start date: 2009-01-12
• Primary completion: 2014-01-01
• Completion: 2019-09-01
• First posted: 2010-03-03
• Last updated: 2021-04-15

Locations

27 sites across 1 country: France