NCT01078129

Cognitive Remediation Therapy and Schizophrenia

Efficacy of Hierarchized Computer-assisted Cognitive Remediation Therapy in Schizophrenia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 77 (actual)
• Sponsor: Hôpital le Vinatier · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Objectives: The purpose of this study is to determine the impact of a new Cognitive Remediation Therapy (CRT) on cognition, social autonomy, symptoms and brain functioning in patients with schizophrenia.

Detailed description

Methods: In a 2 arms blind study versus sham,80 patients with schizophrenia were enrolled in a program consisting of 14 training sessions of 4 cognitive functions (attention/concentration, topological memory, logical reasoning, executive functions)by means REHACOM® software. Measures of cognitive functioning using the Cogtest® battery as well as social autonomy (Social Autonomy Scale, EAS) and schizophrenia symptoms (Positive And Negative Syndrome Scale, PANSS) were undertaken at the beginning and the end of the meetings of remediation. Among those 80 participants, 30 patients to (15 active / 15 sham) were randomized to participate in an fMRI study in order to investigate the impact of such CRT program on brain functioning (n-back task before CRT and 3 months later).

Conditions

• Schizophrenia

Interventions

Type	Name	Description
BEHAVIORAL	cognitive remediation therapy	program consisting of 14 training sessions of 4 cognitive functions (attention/concentration, topological memory, logical reasoning, executive functions)by means REHACOM® software
BEHAVIORAL	non-CRT	waiting list

Timeline

• Start date: 2006-01-01
• Primary completion: 2008-03-01
• Completion: 2010-12-01
• First posted: 2010-03-02
• Last updated: 2014-02-25

Locations

1 site across 1 country: France