Clinical Trials Directory

Trials / Terminated

TerminatedNCT01077440

Presence of Donor-Derived DNA in Semen Samples From Cancer Survivors Who Underwent Donor Stem Cell Transplant

Detection of Donor-Derived DNA in Semen Samples Among Recipients of Allogeneic Hematopoietic Stem-Cell Transplants

Status
Terminated
Phase
—
Study type
Observational
Enrollment
24 (actual)
Sponsor
Vanderbilt University · Academic / Other
Sex
Male
Age
18 Years
Healthy volunteers
Not accepted

Summary

RATIONALE: Studying samples of semen from cancer survivors in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This phase I research study is looking at the presence of donor-derived DNA in semen samples form cancer survivors who underwent donor stem cell transplant.

Detailed description

OBJECTIVES: * To examine semen samples from male survivors of allogeneic hematopoietic stem cell transplantation for the presence of donor-derived DNA. OUTLINE: Semen samples are collected and assessed by flow cytometry and PCR. DNA samples are compared to previously analyzed DNA extracted from survivor and donor. Samples are also analyzed for sperm concentration, motility, morphology, and viability.

Conditions

Interventions

TypeNameDescription
GENETICDNA analysisDNA analysis will be performed on samples collected.
GENETICpolymerase chain reactionA polymerase chain reaction (PCR) assessment will be done on the samples collected.
OTHERflow cytometryFlow cytometry will be done on the samples collected.
OTHERlaboratory biomarker analysisLaboratory biomarker analysis will be performed on the samples collected.

Timeline

Start date
2010-02-01
Primary completion
2014-12-01
Completion
2014-12-01
First posted
2010-03-01
Last updated
2014-12-10

Locations

1 site across 1 country: United States

Source: ClinicalTrials.gov record NCT01077440. Inclusion in this directory is not an endorsement.