NCT01074853

Beta Blockers for the Treatment of Asthma

Evaluation of Beta Blockers for the Treatment of Asthma. A Randomised Controlled Trial of Propranolol

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: University of Dundee · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Current asthma medicines include inhalers. A common inhaler used in asthma is called a beta-agonist (for example salbutamol). They improve asthma symptoms by stimulating areas in the human airway resulting in widening of the human airway. Although these drugs are useful after the first dose, longterm use can cause worsening asthma symptoms. Beta-blockers are the complete opposite type of medication. Just now they are avoided in patients with asthma as after the first dose they can cause airway narrowing and cause an asthma attack. New research has suggested that long term use of beta-blockers can reduce airway inflammation which can improve asthma control and improve symptoms. This research was done in asthmatic patients who didn't need inhaled steroids to control their asthma. What the investigators want to do is see if the same benefit of beta-blocker use is asthma can be seen in people who take inhaled steroids.

Conditions

• Asthma

Interventions

Type	Name	Description
DRUG	propranolol	10mg twice daily escalated to 80mg once daily
DRUG	placebo	Matched placebo

Timeline

• Start date: 2010-05-01
• Primary completion: 2012-03-01
• Completion: 2012-03-01
• First posted: 2010-02-24
• Last updated: 2019-04-12

Locations

1 site across 1 country: United Kingdom