NCT01072916

Serine Proteases in Gastrointestinal Function and Irritable Bowel Syndrome (IBS)

The Role of Serine-Proteases in Gastrointestinal Function and Irritable Bowel Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: University of North Carolina, Chapel Hill · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The proposed pilot project for this seed grant focuses on the role of intestinal serine-proteases in the pathogenesis of diarrhea-predominant IBS (D-IBS). In this study we will further assess serine-protease activity in patients with D-IBS and also explore a possible mechanism by which these proteases can lead to alterations in intestinal physiology and symptoms in these patients. The general hypotheses for the proposed research are that (A) the levels of fecal serine-protease in patients with D-IBS are abnormally increased (B) this abnormal serine-protease activity leads to/is associated with an abnormal increase in intestinal permeability and therefore enables (C) chronic stimulation and activation of the mucosal immune system in these patients. In addition, it is aim to determine whither periodontal inflammation is associated with intestinal permeability and serine protease activity.

Conditions

• Colon, Irritable

Timeline

• Start date: 2009-02-01
• Primary completion: 2015-12-01
• Completion: 2015-12-01
• First posted: 2010-02-22
• Last updated: 2016-03-11

Locations

1 site across 1 country: United States