NCT01071993

Efficacy of Statins In Prevention of CIN

Efficacy Of Statins In The Prevention of Contrast-Induced Nephropathy in Patients With Chronic Renal Insufficiency (SCIN Trial): A Double-Blind, Placebo-Controlled Trial

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: University of Oklahoma · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Accepted

Summary

To determine if statin therapy plus intravenous normal saline, in patients with chronic renal insufficiency undergoing angiography, is superior to placebo plus intravenous normal saline therapy in the prevention of CIN.

Detailed description

Due to the conflict in the available data, there are no practice guidelines that are established in order to prevent contrast-induced nephropathy (CIN). Our goal is to determine if statin therapy plus intravenous normal saline, in patients with chronic renal insufficiency undergoing angiography, is superior to placebo plus intravenous normal saline therapy in the prevention of CIN.

Conditions

• Nephropathy

Interventions

Type	Name	Description
DRUG	placebo	pre-treatment with placebo (80 mg 12 hours prior to the procedure and 40 mg pre-procedure)
DRUG	atorvastatin	pre-treatment with atorvastatin (80 mg 12 hours prior to the procedure and 40 mg pre-procedure)

Timeline

• Start date: 2010-03-01
• Primary completion: 2013-07-01
• Completion: 2013-07-01
• First posted: 2010-02-19
• Last updated: 2017-12-04
• Results posted: 2017-09-13

Locations

2 sites across 1 country: United States