Trials / Completed
CompletedNCT01071226
Peripheral Blood Stem Cell Transplantation Using the CliniMACS Device
CHP 834 Unrelated and Partially Matched Related Donor Peripheral Stem Cell Transplantation With The CliniMACS Device for T and B Cell Depletion
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 60 (actual)
- Sponsor
- Medical College of Wisconsin · Academic / Other
- Sex
- All
- Age
- 22 Years
- Healthy volunteers
- Not accepted
Summary
T cell depletion utilizing the CliniMACS device will allow more precise, specific and controlled graft engineering of peripheral blood stem cells from unrelated and partially matched related donors without an increase in relapse or graft rejection and grade III or IV acute graft versus host disease (GVHD).
Conditions
- Malignant Diseases (ie, Leukemia, MDS, Lymphoma)
- Non-malignant Diseases (ie, Bone Marrow Failure Syndromes)
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | CliniMACS (CD+3, CD+19 depletion) | Patient's in Stratum 1 will receive grafts that have undergone CD3+, CD19+ depletion |
| DEVICE | CliniMACS (CD 34+ positive selection) | Patient's in Stratum 2 will receive peripheral blood progenitor cells that have undergone CD34+ selection |
| OTHER | HSCT | Peripheral Blood Stem Cell Transplant |
Timeline
- Start date
- 2008-05-01
- Primary completion
- 2016-08-01
- Completion
- 2020-04-28
- First posted
- 2010-02-19
- Last updated
- 2021-10-25
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT01071226. Inclusion in this directory is not an endorsement.