NCT01070940

L-NMMA Dose-response Study in Healthy Subjects

L-NMMA's Effect on Renal and Cardiovascular Variables in Healthy Subjects. A Randomized, Placebo-controlled Crossover Study.

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 12 (actual)
• Sponsor: Regional Hospital Holstebro · Academic / Other
• Sex: Male
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate the effect of different levels of nitric oxide inhibition on blood pressure and arterial stiffness in healthy subjects. L-NMMA, an inhibitor of the nitric oxide synthase, is administered as bolus injection followed by continuous infusion, and is expected to raise blood pressure and arterial stiffness according to L-NMMA dose.

Conditions

• Healthy

Interventions

Type	Name	Description
DRUG	NG-monomethyl-L-arginine (L-NMMA)	3 mg/kg IV priming dose + 2 mg/kg/hr IV infusion for 1 hour
DRUG	NG-monomethyl-L-arginine (L-NMMA)	6 mg/kg IV priming dose + 4 mg/kg/hr IV infusion for 1 hour
DRUG	NG-monomethyl-L-arginine (L-NMMA)	4.5 mg/kg IV priming dose + 3 mg/kg/hr IV infusion for 1 hour
DRUG	Placebo	Isotonic saline solution IV priming dose + IV infusion for 1 hour

Timeline

• Start date: 2010-02-01
• Primary completion: 2010-06-01
• Completion: 2010-06-01
• First posted: 2010-02-18
• Last updated: 2011-02-21

Locations

1 site across 1 country: Denmark