NCT01070277

Antiparasitic Treatment for Returning Travelers With Chronic Diarrhea

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Sheba Medical Center · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Study hypotheses is that Antiparasitic therapy in patients with chronic diarrhea after travel to a developing country, with a negative stool findings, will be significantly effective in eliminating diarrhea and other gastro-intestinal complaints compared to similar patients receiving placebo.

Detailed description

It is common to encounter travelers from developing countries who suffer from persistent diarrhea after returning home. In many cases repeated stool samples are negative for bacteria, parasites and helminthes and the cause of the diarrhea is not found. The main debate is whether this condition is a persistent parasitic infection (unidentified) or post-infectious irritable bowel syndrome.However, clinical experience suggests that some of these travelers respond to antiparasitic therapy. This study aims to answer the question whether antiparasitic treatment in these cases is beneficial.

Conditions

• Chronic Diarrhea
• Abdominal Pain
• Bloating

Interventions

Type	Name	Description
DRUG	Tinidazole and Albendazole	Tinidazole 2 gr/daily for 2 days followed by Albendazole 400mg X2 /day for 7 days
DRUG	Placebo control	2 placebo pills X2 /day for 2 days followed by 1 placebo Pill X2 / day for 7 days

Timeline

• Start date: 2012-03-01
• Primary completion: 2015-12-01
• Completion: 2016-12-01
• First posted: 2010-02-18
• Last updated: 2014-08-27

Locations

2 sites across 1 country: Israel