NCT01068093

The Effects of Ezetimibe on Coronary Plaque Volume in Patients With Acute Coronary Syndrome

Assessment of the Effects of Ezetimibe on Coronary Plaque Volume in Patients With Acute Coronary Syndrome

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Yokohama City University Medical Center · Academic / Other
• Sex: All
• Age: 20 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to assess the effects of Ezetimibe on coronary plaque volume in patients with acute coronary syndrome.

Detailed description

Previous studies reported that administration of statins in patients with coronary artery disease resulted in significant reduction of low-density lipoprotein cholesterol(LDL-C) and regression of coronary plaque volume, and a decrease in the level of LDL-C through statin treatment positively correlates with a reduction in the volume of plaques. Administration of Ezetimibe in addition to statin has been shown to be more effective at reducing LDL-C levels compared with statin monotherapy. However, the effects of Ezetimib on coronary plaque volume remain unclear. In this study, the investigators assess the effect of Ezetimibe on coronary plaque volume and tissue composition in patients with acute coronary syndrome.

Conditions

• Coronary Artery Disease

Interventions

Type	Name	Description
DRUG	Ezetimibe	10mg daily

Timeline

• Start date: 2010-10-01
• Primary completion: 2015-10-01
• Completion: 2015-10-01
• First posted: 2010-02-12
• Last updated: 2010-10-22

Locations

1 site across 1 country: Japan