NCT01066247

Premedication and Haemodynamics After Spinal Anesthesia

The Influence of HRV-changing Premedication on Hemodynamic Parameters After Spinal Anesthesia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Medical University of Gdansk · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Blood pressure drop following spinal anesthesia is connected with sympathetic/parasympathetic activity which may be determinated by Heart Rate Variability (HRV) assessment. Sympathetic predomination expressed as LF/HF ratio above 2.5 is strongly connected with deeper blood pressure fall. As drugs given for premedication may have impact on HRV variables, the investigators would like to determine if pharmacological premedication may modify hemodynamic changes following spinal blockade. Two drugs will be compared - midazolam which is known to lead to increase in LF/HF ratio and morphine - opioid which provokes opposite effect.

Conditions

• Hemodynamics After Spinal Anesthesia

Interventions

Type	Name	Description
DRUG	Morphine hydrochloride; Midazolam	intramuscular morphine 10 mg given 30 minutes before spinal blockade performing
DRUG	Midazolam	intramuscular midazolam 15 mg given 30 minutes before spinal blockade performing

Timeline

• Start date: 2009-09-01
• Primary completion: 2010-06-01
• Completion: 2010-06-01
• First posted: 2010-02-10
• Last updated: 2011-07-26

Locations

1 site across 1 country: Poland