NCT01063270

Trial Comparing Efficacy of Treatments for Hidradenitis Suppurativa

Randomized Control Trial Comparing Efficacy of Antibiotic Therapy Alone Versus Antibiotic Therapy in Conjunction With Quadruple Pulse Therapy Using NdYag Laser in Treatment of Hidradenitis Suppurativa

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 18 (actual)
• Sponsor: Henry Ford Health System · Academic / Other
• Sex: All
• Age: 16 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this research study is to further evaluate the efficacy of two treatment regimens for the treatment of hidradenitis suppurativa. This is a randomized controlled study. Patients will be randomly assigned to an arm of the study.

Detailed description

Histological studies suggest that HS is a disease of the follicles with apocrine involvement as a secondary event. The investigators have identified in a previous study that the Nd Yag laser is highly effective for decreasing the inflammation, pain, suppuration and frequency of recurrence of HS. Oral antibiotic therapy with Clindamycin and Rifampin has also been reported in previous studies to be a highly effective treatment regimen for HS and is commonly used by physicians in medical management of HS. The investigators would like to compare the efficacy of NdYag laser treatment combined with antibiotics versus treatment with antibiotics alone. The goal is to evaluate the success of these two treatment regimens on existent HS lesions as well as prevention of recurrence. There will be approximately 18 people in this research study at Henry Ford Health System (HFHS).

Conditions

• Hidradenitis Suppurativa

Interventions

Type	Name	Description
DRUG	Clindamycin & Rifampin	Clindamycin 300mg twice daily for 10 weeks and Rifampin 300mg twice daily for 10 weeks
PROCEDURE	Clindamycin + Rifampin along with NdYag Laser treatment	Clindamycin 300mg twice daily for 2 weeks Rifampin 300mg twice daily for 2 weeks along with 3 NdYag laser sessions.

Timeline

• Start date: 2010-02-01
• Primary completion: 2011-07-01
• Completion: 2013-12-01
• First posted: 2010-02-05
• Last updated: 2022-07-22

Locations

1 site across 1 country: United States