NCT01061346

Effect of Dietary Fat When Eaten With Fructose Versus Glucose

Effect of Dietary Fat When Eaten With Fructose vs. Glucose on Insulin Resistance and Liver Fat

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 19 (actual)
• Sponsor: Pennington Biomedical Research Center · Academic / Other
• Sex: All
• Age: 28 Years – 55 Years
• Healthy volunteers: Accepted

Summary

This study is designed to test the effects on liver fat of varying fat intake in the presence of fructose or glucose. We hypothesize that higher dietary fat when eaten with fructose as compared to glucose will increase the amount of hepatic lipid as measured by magnetic resonance spectroscopy.

Detailed description

After 2 screening visits including an exercise test, DEXA and CT scan, qualifiers begin a 7 day diet with 20% fat, 65% carbohydrate (with 20% glucose) and 15 % protein. Participants consume 2 meals per day at PBRC with lunch and weekend meals packed to go. Following a test day, participants are randomized to one of 3 diet assignments and then test again: 1)20% fat, 65% carbohydrate (with 20% glucose beverage), 15% protein 2)40% fat, 45% carbohydrate (with 20% glucose beverage), 15% protein 3)40% fat, 45% carbohydrate (with 20% fructose beverage), 15% protein On Day 7 and again 14 days later participants have labs, an oral Glucose tolerance test, hepatic and intramuscular lipid measures by MRS, vital signs and waist measurement.

Conditions

• Body Weight Changes

Interventions

Type	Name	Description
OTHER	40% Fat Diet, 20% Fructose Beverage	40% fat, 45% carbohydrate (with 20% fructose beverage), 15% protein
OTHER	20% Glucose Beverage	40% fat, 45% carbohydrate (with 20% glucose beverage), 15% protein
OTHER	20% Glucose Beverage	20% fat, 65% carbohydrate (with 20% glucose beverage), 15% protein

Timeline

• Start date: 2009-10-01
• Primary completion: 2015-03-01
• Completion: 2015-03-01
• First posted: 2010-02-03
• Last updated: 2016-01-25

Locations

1 site across 1 country: United States