NCT01058681

Impacts of Metabolic Variation on Neuroendocrine Control of Reproduction

Impacts of Metabolic Variation on the Activity of Neuroendocrine Reproductive Axis in Healthy Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Centre Hospitalier Universitaire Vaudois · Academic / Other
• Sex: Male
• Age: 18 Years – 25 Years
• Healthy volunteers: Accepted

Summary

This study will evaluate the potential effects of a changing metabolic environment on GnRH hypothalamic neurons, by performing studies of LH pulsatility (basal and during clamp studies) in different groups of male subjects fed isocaloric and hypercaloric diets. The participation of other gastro-intestinal tract hormones to these regulations will be systematically evaluated.

Conditions

• Neuroendocrine Reproductive Status

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	effect of metabolic variations on LH pulsatility	Isocaloric diet: 1,5 times basal metabolism. Constitution:55% carbohydrates, 15% proteins and 30% fat. Hypercaloric diet: addition of 30% fat and 3 g of fructose/kg of weight to isocaloric diet. PO and IV glucose during clamps: PO administration of 90 mg/kg glucose at 90 minutes intervals during the clamp, and adjustment of the IV perfusion to keep euglycemia.

Timeline

• Start date: 2010-01-01
• Primary completion: 2010-10-01
• Completion: 2010-10-01
• First posted: 2010-01-29
• Last updated: 2011-08-03

Locations

1 site across 1 country: Switzerland