Trials / Completed
CompletedNCT01057095
Studying Gene Expression in Tissue Samples From Patients With Acute Myeloid Leukemia
Mechanisms of PLAGL2-Induced Leukaemogenesis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 20 (actual)
- Sponsor
- Children's Oncology Group · Network
- Sex
- All
- Age
- 120 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at gene expression in tissue samples from patients with acute myeloid leukemia.
Detailed description
OBJECTIVES: * Screen acute myeloid leukemia (AML) samples to correlate high relative expression levels of PLAGL2 and putative PLAGL2 target genes (implicated in microarray study) with potential pathogenic relevance with respect to AML development. OUTLINE: Cryopreserved mRNA from diagnostic samples is analyzed for gene expression by reverse transcriptase-PCR.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | RNA analysis | |
| GENETIC | gene expression analysis | |
| GENETIC | reverse transcriptase-polymerase chain reaction | |
| OTHER | laboratory biomarker analysis |
Timeline
- Start date
- 2010-01-01
- Primary completion
- 2010-04-01
- Completion
- 2010-04-01
- First posted
- 2010-01-27
- Last updated
- 2015-10-02
Source: ClinicalTrials.gov record NCT01057095. Inclusion in this directory is not an endorsement.