NCT01056094

Effects of Lutein Supplementation on Oxidative Stress and Inflammation in Healthy Nonsmokers

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Peking University · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Lutein is one of oxygenated carotenoids. Over the past few years, there has been increased interest in evaluating the effect of lutein for optimizing immune functions. A large number of epidemiological studies support the notion that a high intake of lutein is associated with a reduced risk of coronary heart disease and certain types of cancer. The biological mechanisms for the protective effects of this carotenoid, including powerful modulation of functions and antioxidant properties, are only partially known. Although several nutrients and phytochemicals have been shown to modulate immune functions in humans, few studies have investigated the role of lutein consumption. No information is available as to whether lutein supplementation could be protective against oxidative stress. Therefore, the objective of the present study was to examine the effect of consuming different doses of lutein on oxidative stress in healthy subjects.

Detailed description

Participants with a history of smoking, alcohol consumption, body mass index (BMI)≥30kg/m2, allergies, ocular diseases and participants taking vitamins or other food supplements containing lutein were excluded from the study.

Conditions

• Oxidative Stress in Healthy Subjects

Interventions

Type	Name	Description
DRUG	Lutein	Dietary Supplement: 20mg,10mg, 0mg Lutein; daily supplementation 12 week

Timeline

• Start date: 2010-04-01
• Primary completion: 2012-07-01
• Completion: 2012-08-01
• First posted: 2010-01-26
• Last updated: 2012-06-25

Locations

1 site across 1 country: China